Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible? Authors' response
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Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible? Authors' response
Page 1 of 1 (page number not for citation purposes) We thank Dr Wang and Dr Luo for their interest in our paper demonstrating the ability of intervertebral disc cells to undergo phagocytosis [1], and we can certainly concur with some of the points they raise [2]. In fact, we addressed the first point in the last paragraph of the Discussion, stating that ‘Although disc cells usually occur in iso...
متن کاملNucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible?
We have read with interest the research article by Philip Jones and colleagues, in which they studied whether bovine nucleus pulposus (NP) cells were capable of behaving as phagocytes [1]. Collectively, they drew the conclusion that disc cells clearly can undergo phagocytosis, which has implications for the intervertebral disc in vivo. We would like to differ from the authors, however, regardin...
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Engulfment of apoptotic cells by phagocytes is important throughout development and adult life. When phagocytes engulf apoptotic cells, they increase their cellular contents including cholesterol and phospholipids, but how the phagocytes respond to this increased load is poorly understood. Here, we identify one type of a phagocyte response, wherein the recognition of apoptotic cells triggers en...
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INTRODUCTION The cells of the embryonic notochord play an important role in formation of the spinal column, including the intervertebral discs (IVDs) (1). These cells become trapped inside the annulus fibrosus and reside within the nucleus pulposus at birth, but are generally lost during aging and replaced by small chondrocyte-like cells. The age at which the notochordal cells are lost varies s...
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Objective(s): This research is to study the influences of different concentrations of simvastatin on the biological activities of nucleus pulposus-derived mesenchymal stem cells (NPMSC).Materials and Methods: NPMSC were cultured with different concentrations of simvastatin (0, 0.01, 0.1, and 1 μM) and assessed to determine the possible e...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2009
ISSN: 1478-6354
DOI: 10.1186/ar2672